OpenEvidence
AI HealthcareFree
Free AI-powered medical search engine for verified clinicians delivering cited, evidence-based answers from peer-reviewed literature in seconds.
0 upvotesintermediate
Compare OpenEvidence vs UpToDate Expert AI
Both tools in AI Healthcare
UpToDate Expert AI
AI HealthcarePaid
Generative AI-powered clinical decision support built on UpToDate's 30-year evidence base, reviewed by 7,600+ medical experts, adopted by 2,000+ US hospitals.
0 upvotesintermediate
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Pricing
Pricing Comparison
OpenEvidence
Free$0
Full access for verified US clinicians, funded by pharmaceutical ads
Enterprise$Custom
Epic EHR integration and health system-wide deployment
UpToDate Expert AI
Pro Plus$579/yr
Individual subscription with Expert AI included
Enterprise$Custom
Health system-wide access, EHR integration, governance controls
Features
Feature Comparison
OpenEvidence
Quick Consult (Rapid Answer Mode)Deep Consult (Multi-Source Synthesis)Inline Journal CitationsNEJM and JAMA Content PartnershipAMA and NCCN Guideline AccessAmbient Documentation (Visits)HIPAA-Compliant Doctor DialerICD-10 and Coding IntelligenceLock Screen and Home Screen WidgetsiOS and Android Native AppsWeb Interface AccessEpic EHR Integration (Sutter Health)Evidence Search in Natural LanguageVerified Clinician-Only AccessSOC 2 Type II CertifiedPharmaceutical Ad-Funded Free Access20M+ Monthly Clinical Consultations
UpToDate Expert AI
Clinical Intelligence FrameworkClosed-Content AI (No Hallucinations)7,600+ Expert Contributor Network13,000+ Clinical Topics Coverage25 Medical SpecialtiesInline Reasoning and Assumptions DisplayStep-by-Step Clinical RationaleSource-Linked CitationsLexidrug Drug Information IntegrationCME Credit for AI InteractionsACCME-Accredited CME ProviderEpic and EHR Workflow IntegrationAbridge and Dragon Copilot IntegrationEnterprise Governance FrameworkShadow AI Risk MitigationOpenAI Model Powered BackendClinical Hallucination Elimination Design
Fit
Best For & Not For
OpenEvidence
✅ Best For
✅Verified US physicians, residents, NPs, and PAs who need instant, cited answers to clinical questions during hospital rounds, ED shifts, or primary care visits without the cost of UpToDate. Clinicians who want an AI-native alternative to manual PubMed or guideline searches, especially in time-pressured settings.
❌ Not For
❌Patients or non-clinicians without verified healthcare credentials, as OpenEvidence requires professional verification. Clinicians who need differential diagnosis generation or advanced drug dosing calculators, as those features are not yet available in the core platform.
UpToDate Expert AI
✅ Best For
✅Clinicians and health systems that already use UpToDate and want a trusted, hallucination-free GenAI upgrade to their existing clinical decision support workflow. Medical students, residents, and individual practitioners on UpToDate Pro Plus who need fast, evidence-based answers with transparent reasoning — and now earn CME credit while doing so.
❌ Not For
❌Clinicians looking for a free or low-cost alternative to UpToDate, as Expert AI is available exclusively within paid UpToDate Enterprise or Pro Plus subscriptions. Organizations that need ambient documentation or clinical note generation, as UpToDate Expert AI is a knowledge Q&A tool, not an AI scribe.
Availability
Platform & Accessibility
OpenEvidence
web-basedmobile
UpToDate Expert AI
web-basedmobileapi
Use & Audience
Tasks & Who It's For
Integrations
Integrations
OpenEvidence
Other
EpicNEJMJAMAAMA
UpToDate Expert AI
Other
EpicDragon CopilotAbridgeLexidrug
Use Cases
Real-world Use Cases
OpenEvidence
1
Dr. Nguyen, a hospitalist on call at 2 AM, uses OpenEvidence to quickly check the latest evidence on anticoagulation dosing for a patient with atrial fibrillation and severe renal impairment, getting a cited answer in 8 seconds instead of searching three reference tools.2
A third-year internal medicine resident uses Deep Consult before attending rounds to synthesize all current evidence on immune checkpoint inhibitor toxicity management, arriving with structured answers that impress her attending and reduce rounds time by 20 minutes.3
An NP in a rural clinic without an UpToDate subscription uses OpenEvidence as her daily clinical reference, getting the same evidence quality for free and reducing the number of specialist referrals by consulting guidelines in real time.UpToDate Expert AI
1
Dr. Sonday, Associate CMIO at St. Luke's University Health Network, describes UpToDate Expert AI as a smarter, faster way to get trusted answers that feel like having a conversation with a clinical colleague, replacing his previous habit of searching three reference tools for complex cases.2
A pharmacy resident uses Expert AI's Lexidrug integration to verify a complex drug interaction in a patient on 12 medications, receiving a structured response with dosing adjustments in 15 seconds and earning CME credit for the interaction.3
A chief medical officer at a 400-bed community hospital deploys Expert AI enterprise-wide after seeing that 40% of physicians were using unauthorized general AI tools for clinical questions, replacing shadow AI with a governed, hallucination-free alternative.Keep Exploring
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