UpToDate Expert AI

UpToDate Expert AI

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Generative AI-powered clinical decision support built on UpToDate's 30-year evidence base, reviewed by 7,600+ medical experts, adopted by 2,000+ US hospitals.

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What is UpToDate Expert AI?

UpToDate Expert AI is Wolters Kluwer's generative AI evolution of UpToDate, the gold-standard clinical decision support platform used by 3+ million clinicians at thousands of hospitals worldwide. Launched in Q4 2025, Expert AI combines a chatbot-style interface with UpToDate's Clinical Intelligence Framework, which grounds every response exclusively in UpToDate's expert-authored, peer-reviewed content maintained by 7,600+ medical experts across 13,000+ clinical topics in 25 specialties. Unlike open AI models, Expert AI produces zero hallucination risk by operating in a closed, governed content environment. Each response includes clinical assumptions, step-by-step reasoning, and direct source links. Uniquely, Expert AI now awards CME credit for eligible interactions, integrating professional development into daily clinical workflows. As of May 2026, over half of Epic enterprise hospitals in the US have signed up for Expert AI adoption. Powered by OpenAI models via an expanded enterprise collaboration announced June 2026.

Key Features

Clinical Intelligence FrameworkClosed-Content AI (No Hallucinations)7,600+ Expert Contributor Network13,000+ Clinical Topics Coverage25 Medical SpecialtiesInline Reasoning and Assumptions DisplayStep-by-Step Clinical RationaleSource-Linked CitationsLexidrug Drug Information IntegrationCME Credit for AI InteractionsACCME-Accredited CME ProviderEpic and EHR Workflow IntegrationAbridge and Dragon Copilot IntegrationEnterprise Governance FrameworkShadow AI Risk MitigationOpenAI Model Powered BackendClinical Hallucination Elimination Design

Integrations

Other
EpicDragon CopilotAbridgeLexidrug

How to Use UpToDate Expert AI

1Access UpToDate Expert AI through your institutional UpToDate Enterprise Edition subscription or UpToDate Pro Plus individual plan
2Log into the UpToDate interface and select the Expert AI chat mode
3Type your clinical question in natural language as you would ask a colleague
4Review the AI-generated answer with the clinical reasoning, key assumptions, and source links displayed below
5Click through to the full UpToDate topic for complete guideline detail, or earn CME credit for the interaction

✅ Best For

  • Clinicians and health systems that already use UpToDate and want a trusted, hallucination-free GenAI upgrade to their existing clinical decision support workflow. Medical students, residents, and individual practitioners on UpToDate Pro Plus who need fast, evidence-based answers with transparent reasoning — and now earn CME credit while doing so.

❌ Not For

  • Clinicians looking for a free or low-cost alternative to UpToDate, as Expert AI is available exclusively within paid UpToDate Enterprise or Pro Plus subscriptions. Organizations that need ambient documentation or clinical note generation, as UpToDate Expert AI is a knowledge Q&A tool, not an AI scribe.

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Pricing

Pro Plus$579/yr
  • ✓Individual subscription with Expert AI included
EnterpriseCustom
  • ✓Health system-wide access
  • ✓EHR integration
  • ✓governance controls

Prompts to Try

What is the recommended antibiotic regimen for hospital-acquired pneumonia in a ventilated patient with known MRSA colonization?

How should I manage a patient with type 2 diabetes who develops heart failure with reduced ejection fraction?

What does the evidence say about the safety of rivaroxaban in patients with antiphospholipid syndrome?

Use Cases

Dr. Sonday, Associate CMIO at St. Luke's University Health Network, describes UpToDate Expert AI as a smarter, faster way to get trusted answers that feel like having a conversation with a clinical colleague, replacing his previous habit of searching three reference tools for complex cases.
A pharmacy resident uses Expert AI's Lexidrug integration to verify a complex drug interaction in a patient on 12 medications, receiving a structured response with dosing adjustments in 15 seconds and earning CME credit for the interaction.
A chief medical officer at a 400-bed community hospital deploys Expert AI enterprise-wide after seeing that 40% of physicians were using unauthorized general AI tools for clinical questions, replacing shadow AI with a governed, hallucination-free alternative.
An internal medicine attendee uses Expert AI's step-by-step reasoning display to teach medical students on rounds, using the AI's explicit clinical logic as a teaching scaffold to build evidence-based reasoning skills.
A hospitalist managing a complex case of decompensated heart failure with cardiorenal syndrome queries Expert AI and receives a treatment strategy with explicit clinical assumptions, sharing it with the cardiology consultant to align on a jointly defensible plan.

Frequently Asked Questions