OpenEvidence
FreeFree AI-powered medical search engine for verified clinicians delivering cited, evidence-based answers from peer-reviewed literature in seconds.
What is OpenEvidence?
OpenEvidence is the fastest-growing clinical AI platform in US history, used by over 757,000 verified physicians across 10,000+ hospitals and medical centers, representing more than 40% of practicing US doctors as of early 2026. Founded by Harvard and MIT-trained researchers and launched through the Mayo Clinic Platform Accelerate program, OpenEvidence delivers AI-synthesized answers to complex clinical questions grounded exclusively in peer-reviewed medical literature from partners including NEJM, JAMA, AMA, NCCN, ACC, and AAFP. Its Quick Consult feature delivers rapid answers, while Deep Consult runs multi-source literature synthesis for complex cases. In 2025, OpenEvidence launched Visits (ambient clinical documentation) and an AI-Integrated Doctor Dialer for secure patient communication. Valued at $12 billion following a $250M Series D in January 2026, the platform is free for verified clinicians and funded through pharmaceutical advertising with CPMs of $70-$150+.
Key Features
Integrations
How to Use OpenEvidence
✅ Best For
- Verified US physicians, residents, NPs, and PAs who need instant, cited answers to clinical questions during hospital rounds, ED shifts, or primary care visits without the cost of UpToDate. Clinicians who want an AI-native alternative to manual PubMed or guideline searches, especially in time-pressured settings.
❌ Not For
- Patients or non-clinicians without verified healthcare credentials, as OpenEvidence requires professional verification. Clinicians who need differential diagnosis generation or advanced drug dosing calculators, as those features are not yet available in the core platform.
Reviews
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Pricing
- ✓Full access for verified US clinicians
- ✓funded by pharmaceutical ads
- ✓Epic EHR integration and health system-wide deployment
Prompts to Try
What is the first-line treatment for community-acquired pneumonia in a patient with CKD stage 3?
What does the latest evidence say about GLP-1 receptor agonists in heart failure with reduced ejection fraction?
What are the NCCN guidelines for adjuvant chemotherapy in stage II colon cancer?
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